Journal article
Neural correlates of moral sensitivity in obsessive-compulsive disorder
BJ Harrison, J Pujol, C Soriano-Mas, R Hernández-Ribas, M López-Solà, H Ortiz, P Alonso, J Deus, JM Menchon, E Real, C Segalàs, O Contreras-Rodríguez, L Blanco-Hinojo, N Cardoner
Archives of General Psychiatry | AMER MEDICAL ASSOC | Published : 2012
Abstract
Context: Heightened moral sensitivity seems to characterize patients with obsessive-compulsive disorder (OCD). Recent advances in social cognitive neuroscience suggest that a compelling relationship may exist between this disorder-relevant processing bias and the functional activity of brain regions implicated in OCD. Objective: To test the hypothesis that patients withOCD demonstrate an increased response of relevant ventromedial prefrontal and orbitofrontal cortex regions in a functional magnetic resonance imaging study of difficult moral decision making. Design: Case-control cross-sectional study. Setting: Hospital referral OCD unit and magnetic resonance imaging facility. Participants: S..
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Grants
Awarded by Centro de Investigacion en Red de Salud Mental (FIS)
Awarded by Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR)
Awarded by Ministry of Education and Science of Spain
Awarded by National Health and Medical Research Council of Australia Clinical Career Development Award
Awarded by Carlos III Health Institute
Funding Acknowledgements
This study was supported in part by the Instituto de Salud Carlos III, Centro de Investigacion en Red de Salud Mental (FIS, ID PI050884, PI071029, PS09/01331, PI10/01003, and CP10/00604), the Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR; 20009SGR1554), and the Ministry of Education and Science of Spain (SAF2010-19434). Dr Harrison is supported by a National Health and Medical Research Council of Australia Clinical Career Development Award (ID 628509). Dr Soriano-Mas is supported by a "Miguel Servet" contract from the Carlos III Health Institute (ID CP10/00604). Drs Lopez-Sola and Deus are members of the Research Group SGR-1450 of the Agency of University and Research Funding Management of the Catalan Government.